2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

The liver performs an essential role in metabolism of vitamin D (VD); deficiency of vitamin K, another fat-soluble vitamin, is common in cats with cholestatic hepatobiliary disease (CHD). We hypothesized that VD levels in cats with CHD would be significantly lower than in normal cats or sick cats with non-hepatobiliary disorders. A prospective case control study was done comparing cats with CHD disease (defined by hyperbilirubinemia and increased alanine aminotransferase), sick cats without hepatobiliary disease, and normal cats repre- Sixty-nine studies, including seven conference abstracts, reporting perioperative and/or clinical and/or surgical/interventional outcomes of dogs managed with one surgical/interventional technique and/or medical management for cEHPSS were identified. Only 19 studies were designed as prospective studies, including one non-blinded randomized controlled clinical trial, one non-blinded non-randomized controlled clinical trial and 17 uncontrolled clinical trials. The majority of the studies showed overall high risk of bias and evaluated low to very low numbers of cases per treatment group (67%) but with clearly characterized subject enrolment criteria (97%).