2015 ACVIM Forum Research Abstract Program

Gender included 8 MN, 2 FS and 7 MN, 3 FS for groups 1 and 2 respectively. The average age of group 1 cats was 9.8 yr (5-14 yrs). The average age of group 2 cats was 10.5 yrs (9-15 yrs). Group 1 cats were all DSH, Group 2 cats included 8 DSH, 1 DLH, and 1 Maine Coon. Group 1 cats had been diagnosed 7-14 days previously except for 1 cat that had been diagnosed 3 months previously. Group 2 cats had been treated with ProZinc R for 3 mos-4 years. Four cats in group 1 were being fed low carbohydrate diets; 8 cats in group 2 were fed low carbohydrate diets with 9 of them being fed free choice. Glucose curve data from group 1 cats showed an average onset of action of ProZinc R of 30 min (peakless-60 min), duration of action of 18.5 hrs (11.5-23 hrs), and time to peak activity of 9 hrs (peakless-14 hrs). The glucose nadir ranged from 80-200 mg/dl. Group 2 cats were receiving an average insulin dose of 0.57 U/kg (0.14-0.99 U/Kg). 9 cats were receiving ProZinc R bid, and 1 cat sidbid. In group 2 cats, the average onset of action of ProZinc R was 37 min (30-60 min), duration of action was11-> 12 hrs, and time to peak activity was 5.8 hrs (peakless-7 hrs). The blood glucose nadir was 50-180 mg/dl. Owner-supplied follow-up data on group 1 cats revealed that 7 cats were doing well on ProZinc R , given twice daily, and 2 cats were being treated with once daily Pro-Zinc R . One cat became euglycemic for 3 weeks before requiring insulin again. Clinical signs, including plantigrade stance in 2 cats, improved or completely resolved. For the group 2 cats, 3 cats increased ProZinc R dose and 2 cats decreased ProZinc R dose as a result of glucose monitoring.