Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_1
Snippet: Down-regulated gene expression, encoding sarcoplasmic reticulum (SR) Ca 2 + -ATPase and its regulatory proteins such as SR Ca 2 + -ATPase isoform 2a (SERCA2a) and phospholamban (PLN), plays a crucial role in myocardial decompensation due to the impairment of intracellular Ca 2+ cycling. It has been reported that SERCA2a and PLN expressed in peripheral blood mononuclear cells (PBMC) not only are translatable to the myocardial setting, but also sig.....
Document: Down-regulated gene expression, encoding sarcoplasmic reticulum (SR) Ca 2 + -ATPase and its regulatory proteins such as SR Ca 2 + -ATPase isoform 2a (SERCA2a) and phospholamban (PLN), plays a crucial role in myocardial decompensation due to the impairment of intracellular Ca 2+ cycling. It has been reported that SERCA2a and PLN expressed in peripheral blood mononuclear cells (PBMC) not only are translatable to the myocardial setting, but also significantly decrease in dogs with degenerative mitral valve disease. The aim of this study is to clarify how effectively the target genes reflect hemodynamic overload, a primary determinant of myocardial distress.
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