2015 ACVIM Forum Research Abstract Program

ProZinc R effectively lowers blood glucose and controls clinical signs in cats with diabetes mellitus for up to 4 years. The onset of action and duration of actions of ProZinc R indicate bid therapy for optimal control. However, the duration of action or Pro-Zinc R in some cats is greater than 12 hours and it may be used as a once per day therapy if owners cannot comply with twice daily insulin administration. Diabetic remission, defined as the ability to maintain euglycemia without insulin administration, occurs in over 80% of newly diagnosed diabetic cats, provided tight glycemic control is instituted early after diagnosis. However, approximately 25-30% of cats in remission relapse, and require further insulin therapy to control blood glucose. The majority of diabetic cats in remission have impaired glucose tolerance, and 19% have impaired fasting blood glucose, indicating that these cats do not have normal glucose metabolism. Except for documentation of impaired glucose tolerance, the metabolic disturbances in diabetic cats in remission are poorly understood. The aim of this study was to determine metabolic profiles of cats in remission using gas chromatography mass spectrometry (GC-MS), and to compare them to healthy control cats.