Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_626
Snippet: Dogs with CKD may have platelet dysfunction, but are hypercoagulable based on elevated TEG values. Platelet receptor expression may not explain changes in platelet function and coagulation Eighteen healthy beagle dogs were used. In group 1 (n = 6), NM was administered at the dose of 0.5 mg/kg/h during 5 hours of IHD. In group 2 (n = 6), NM was administered at the lower dose of 0.25 mg/kg/h during IHD. In group 3 (n = 6), which is the control grou.....
Document: Dogs with CKD may have platelet dysfunction, but are hypercoagulable based on elevated TEG values. Platelet receptor expression may not explain changes in platelet function and coagulation Eighteen healthy beagle dogs were used. In group 1 (n = 6), NM was administered at the dose of 0.5 mg/kg/h during 5 hours of IHD. In group 2 (n = 6), NM was administered at the lower dose of 0.25 mg/kg/h during IHD. In group 3 (n = 6), which is the control group, unfractionated heparin was administered during IHD. Evaluation parameters included residual blood clot in blood chamber and dialyzer arterial sides, hemoglobin, hemato-crit, platelets, prothrombin time (PT), activated partial thromboplastin time (aPTT) and activated clotting time (ACT).
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