Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_742
Snippet: Regulatory T-cells (Tregs) are necessary both for maintenance of a healthy immune system and for prevention of autoimmune pathology. Abnormalities in Treg number or function have been implicated in multiple autoimmune, infectious and allergic diseases. In rodents and in humans, aspirin and cyclosporine have both been shown to affect Treg number and function and T-cell cytokine production. In dogs, however, it has not yet been determined if either.....
Document: Regulatory T-cells (Tregs) are necessary both for maintenance of a healthy immune system and for prevention of autoimmune pathology. Abnormalities in Treg number or function have been implicated in multiple autoimmune, infectious and allergic diseases. In rodents and in humans, aspirin and cyclosporine have both been shown to affect Treg number and function and T-cell cytokine production. In dogs, however, it has not yet been determined if either drug influences Treg numbers, nor has it been determined if concurrent aspirin alters the immunosuppressive effects of cyclosporine. Our study was designed to determine the effects of cyclosporine, low-dose aspirin, high-dose aspirin and concurrent cyclosporine and lowdose aspirin on canine Treg numbers and T-cell cytokine expression.
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