Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_762
Snippet: Three purpose-bred cats with unremarkable CBC, serum biochemistry and urinalyses were utilized. The following procedures were performed (minimum 7 day wash out): A) 3.75 mg and 7.5 mg TM once aurally with 48 hour PK sampling (Serum samples were obtained via jugular catheter at 0, 0.5, 1, 2, 5, 9, 12, 24, 36 and 48 hours) , B) 7.5 mg TM and placebo daily aurally for six consecutive days then 48 hour PK C) 1.87 mg mirtazapine orally once with limit.....
Document: Three purpose-bred cats with unremarkable CBC, serum biochemistry and urinalyses were utilized. The following procedures were performed (minimum 7 day wash out): A) 3.75 mg and 7.5 mg TM once aurally with 48 hour PK sampling (Serum samples were obtained via jugular catheter at 0, 0.5, 1, 2, 5, 9, 12, 24, 36 and 48 hours) , B) 7.5 mg TM and placebo daily aurally for six consecutive days then 48 hour PK C) 1.87 mg mirtazapine orally once with limited serum sampling at 1, 4 and 8 hours. Kibble weight was recorded every 2 hours during B and C. Serum mirtazapine and compounded gel concentrations were measured using liquid chromatography/tandem mass spectrometry. Non-compartmental pharmacokinetic modeling was performed. Oral dose AUC values were estimated using a limited sampling model developed from previous study data.
Search related documents:
Co phrase search for related documents- auc value and pk sampling: 1
- auc value and sampling model: 1
- chromatography tandem and jugular catheter: 1, 2
- chromatography tandem and liquid chromatography tandem mass spectrometry: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- chromatography tandem and liquid chromatography tandem mass spectrometry measure: 1
- chromatography tandem and mass spectrometry: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- chromatography tandem and sampling model: 1
- chromatography tandem and serum biochemistry: 1, 2
- chromatography tandem and Serum mirtazapine: 1
- chromatography tandem and urinalysis serum biochemistry: 1
- chromatography tandem mass spectrometry and jugular catheter: 1, 2
- chromatography tandem mass spectrometry and liquid chromatography tandem mass spectrometry: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- chromatography tandem mass spectrometry and liquid chromatography tandem mass spectrometry measure: 1
- chromatography tandem mass spectrometry and mass spectrometry: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- chromatography tandem mass spectrometry and sampling model: 1
- chromatography tandem mass spectrometry and serum biochemistry: 1, 2
- chromatography tandem mass spectrometry and Serum mirtazapine: 1
- chromatography tandem mass spectrometry and urinalysis serum biochemistry: 1
- consecutive day and serum sample: 1
Co phrase search for related documents, hyperlinks ordered by date