Author: McWhirter, Sarah M.; Barbalat, Roman; Monroe, Kathryn M.; Fontana, Mary F.; Hyodo, Mamoru; Joncker, Nathalie T.; Ishii, Ken J.; Akira, Shizuo; Colonna, Marco; Chen, Zhijian J.; Fitzgerald, Katherine A.; Hayakawa, Yoshihiro; Vance, Russell E.
Title: A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP Document date: 2009_8_31
ID: 3b8b8p61_14
Snippet: In this study, we provide evidence that mammalian cells survey their cytosol for the presence of c-di-GMP. We find that c-di-GMP triggers a transcriptional response virtually indistinguishable from the response triggered by cytosolic DNA. Like the response to DNA, the response to c-di-GMP requires the TBK1 kinase and IRF3 transcription factor. However, the pathway for sensing c-di-GMP can be distinguished from that for sensing DNA in certain cell.....
Document: In this study, we provide evidence that mammalian cells survey their cytosol for the presence of c-di-GMP. We find that c-di-GMP triggers a transcriptional response virtually indistinguishable from the response triggered by cytosolic DNA. Like the response to DNA, the response to c-di-GMP requires the TBK1 kinase and IRF3 transcription factor. However, the pathway for sensing c-di-GMP can be distinguished from that for sensing DNA in certain cell types and, moreover, appears to be distinct from all other known cytosolic sensing pathways. Our results suggest a novel mechanism by which host cells can induce an inflammatory response to a widely produced bacterial ligand.
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