Author: Jaïs, Philippe H; Decroly, Etienne; Jacquet, Eric; Le Boulch, Marine; Jaïs, Aurélien; Jean-Jean, Olivier; Eaton, Heather; Ponien, Prishila; Verdier, Fréderique; Canard, Bruno; Goncalves, Sergio; Chiron, Stéphane; Le Gall, Maude; Mayeux, Patrick; Shmulevitz, Maya
Title: C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system Document date: 2019_3_18
ID: 6nq7y1qe_86
Snippet: In conclusion, the C3P3-G1 artificial expression system recapitulates the key mRNA modifications required for mRNA translation, including RNA synthesis, capping, and in part polyadenylation. This system is optimized for mammals, although it can theoretically be adapted to any other eukaryotic species. The C3P3 system should be seen as a versatile system, with multiple in cellulo and in vivo applications. Importantly, the present C3P3-G1 system sh.....
Document: In conclusion, the C3P3-G1 artificial expression system recapitulates the key mRNA modifications required for mRNA translation, including RNA synthesis, capping, and in part polyadenylation. This system is optimized for mammals, although it can theoretically be adapted to any other eukaryotic species. The C3P3 system should be seen as a versatile system, with multiple in cellulo and in vivo applications. Importantly, the present C3P3-G1 system should be considered as an advanced prototype, which performances will be strongly improved in further generations without doubt.
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