2015 ACVIM Forum Research Abstract Program

Cats with CC and IMC showed significant clinical improvement after SIVOY TM treatment, and histological parameters suggest a potential anti-inflammatory effect of SIVOY TM , associated with a reduction of mucosal infiltration, and restoration of the number of ICC. The evaluation of microbiota composition after probiotic treatment is in progress to further understand the effects of probiotic therapy on chronic constipation in cats. Chronic pancreatitis (CP) in dogs is a clinically underdiagnosed condition characterized by acinar cell atrophy, fibrosis, and loss of exocrine function. Currently, there is no approved pharmaceutical treatment for chronic pancreatitis in dogs, thus management relies heavily on supportive care. Camostat mesilate (CM; FOY-305) is a synthetic protease inhibitor, which has been shown to have inhibitory effects on trypsin, the kinin system, as well as inflammatory and fibrotic cascades. CM has been approved for the treatment of chronic pancreatitis in humans in Japan for over 20 years. However, data on the efficacy of CM in dogs with chronic pancreatitis are lacking. Thus, the purpose of this study was to evaluate the effects of oral CM therapy on markers of acinar cell damage, inflammation, and fibrosis in dogs with suspected CP.