Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

Lee, Hyun Jun; Seo, Young Eun; Han, Seung Beom; Jeong, Dae Chul; Kang, Jin Han

group had a significantly higher tendency for underlying medical conditions (P = 0.020), LRTI (P = 0.011), and need for oxygen therapy (P = 0.029), compared with children in the ADV group (Table 2) . However, the duration of fever and hospitalization was not significantly different between the two groups ( Table 2) . Among laboratory test results, only absolute lympho-cyte count (ALC) showed a significant difference between the two study groups ( Table 3) . The ESR and CRP levels were lower in the coinfection group than in the ADV group; however, this difference was not statistically significant (Table 3 ). In a multivariate analysis, only the younger age was significantly associated with respiratory viral coinfection (P <0.001, Table 4 ). As rhinovirus and RSV were the most common coinfected viruses, the ADV group was also compared with the ADV and rhinovirus coinfection group and the ADV and RSV coinfection group (Table 2) . Children in the ADV and rhinovirus coinfection group tended to be younger and have more underlying medical conditions, and LRTIs compared with those in the ADV group; however, they did not receive more oxygen therapy. Similarly, children in the ADV and RSV coinfection group also tended to be younger, have more underlying medical conditions, and receive more oxygen therapy compared with those in the ADV group; however, the proportion of children with LRTIs was not significantly different between the two coinfection groups.