Author: Xia, Shuai; Yan, Lei; Xu, Wei; Agrawal, Anurodh Shankar; Algaissi, Abdullah; Tseng, Chien-Te K.; Wang, Qian; Du, Lanying; Tan, Wenjie; Wilson, Ian A.; Jiang, Shibo; Yang, Bei; Lu, Lu
Title: A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike Document date: 2019_4_10
ID: 3c5ab73l_7
Snippet: On the basis of the 6-HB fusion core structure, we previously reported on peptides MERS-HR1P and MERS-HR2P that were derived from MERS-CoV HR1 and HR2, respectively (fig. S1C), and these two peptides displayed good interaction with each other (27) . Here, we located the conserved HR region of multiple HCoVs by sequence comparisons and then synthesized HR1-and HR2-derived peptides, termed HR1P and HR2P (Fig. 1C) . Notably, we observed 14-amino aci.....
Document: On the basis of the 6-HB fusion core structure, we previously reported on peptides MERS-HR1P and MERS-HR2P that were derived from MERS-CoV HR1 and HR2, respectively (fig. S1C), and these two peptides displayed good interaction with each other (27) . Here, we located the conserved HR region of multiple HCoVs by sequence comparisons and then synthesized HR1-and HR2-derived peptides, termed HR1P and HR2P (Fig. 1C) . Notably, we observed 14-amino acid insertions in both HR1P and HR2P in the HRs of two ï¡-HCoVs, i.e., 229E and NL63.
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