2015 ACVIM Forum Research Abstract Program

TK and c-CRP were significantly increased in poorly-versus well-controlled dogs (P = 0.038, P = 0.007, respectively). Poorlyvs. well-controlled median concentrations for TK were 46.9 and 8.45 U/L (ref <2U/L) and for cCRP 29.8 and 1.1 mg/L (ref <2 mg/L). All but two dogs were vitamin D insufficient (defined as <100 ng/mL) with meanAESD all samples, 51 AE 27 ng/mL. TK and c-CRP warrant further investigation as biomarkers for monitoring immune-mediated disease control. Vitamin D insufficiency may suggest supplementation could improve therapeutic response or reduce disease risk, though additional study is needed. Adipose-derived mesenchymal stem cells (aMSC) have recently been investigated as an immunomodulatory therapy in cats with chronic kidney disease and asthma. The influence of age on the proliferative and immunomodulatory potential of feline aMSC has not been explored, which has implications for autologous versus allogeneic therapy. The purpose of this study was to compare telomere length, ability to proliferate in culture and ability to suppress lymphocyte proliferation of aMSC generated from young and geriatric cats.