Author: Alba Grifoni; John Sidney; Yun Zhang; Richard H Scheuermann; Bjoern Peters; Alessandro Sette
Title: Candidate targets for immune responses to 2019-Novel Coronavirus (nCoV): sequence homology- and bioinformatic-based predictions Document date: 2020_2_20
ID: 8p1agcm2_10
Snippet: We also aligned the SARS-CoV T cell epitope sequences and calculated for each epitope the percentage identity to 2019-nCoV. For each T cell epitope, Table 3 shows the antigen of origin, the epitope sequence, the homologous 2019-nCoV sequence, and corresponding percentage of sequence identity. Overall, the nucleocapsid phosphoprotein and membranederived epitopes were most conserved (8/10 and 2/3, respectively, had ≥ 85% identity with 2019-nCoV)......
Document: We also aligned the SARS-CoV T cell epitope sequences and calculated for each epitope the percentage identity to 2019-nCoV. For each T cell epitope, Table 3 shows the antigen of origin, the epitope sequence, the homologous 2019-nCoV sequence, and corresponding percentage of sequence identity. Overall, the nucleocapsid phosphoprotein and membranederived epitopes were most conserved (8/10 and 2/3, respectively, had ≥ 85% identity with 2019-nCoV). The Orf1ab and surface glycoprotein epitopes were moderately conserved (3/7 and 10/23, respectively, had ≥ 85% identity with 2019-nCoV), and Orf 3a epitopes were the least conserved.
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