Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_681
Snippet: This study evaluated the safety of capromorelin in dogs. Thirty-two Beagle dogs were randomly assigned to four groups (n = 4/sex/group) and received 0, 0.39, 9.2 or 52.4 mg/kg capromorelin (dose calculated per the tartrate salt) once daily by oral gavage for 12 consecutive months. Safety parameters were evaluated including clinical signs, food consumption, body weight, clinical pathology, urinalysis, ophthalmology, electrocardiogram and vital sig.....
Document: This study evaluated the safety of capromorelin in dogs. Thirty-two Beagle dogs were randomly assigned to four groups (n = 4/sex/group) and received 0, 0.39, 9.2 or 52.4 mg/kg capromorelin (dose calculated per the tartrate salt) once daily by oral gavage for 12 consecutive months. Safety parameters were evaluated including clinical signs, food consumption, body weight, clinical pathology, urinalysis, ophthalmology, electrocardiogram and vital signs. Capromorelin, GH and IGF-1 were measured in plasma samples collected at various timepoints during the study. At the end of the dosing period, dogs were euthanized and necropsied. Selected organs were weighed and tissue samples collected and processed for microscopic examination.
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