2015 ACVIM Forum Research Abstract Program

Cats receiving TM for 6 days had a significant increase in appetite (P = 0.0078), rate of food ingestion (P = 0.0078), activity level (P = 0.0078), begging (P = 0.0078) and vocalization (P = 0.0039) when compared to placebo. On day 6, cats receiving TM had a significant increase in food consumption in hospital (P = 0.0435) when compared to placebo but vocalization and activity were not statistically different between treatments. Gel concentrations were 105 AE 11% of target dose. Average AE SD trough and peak serum mirtazapine concentrations after 6 days of TM administration were 21 AE 14.9 ng/mL and 35 AE 18.2 ng/ mL respectively. Serum ALT remained normal after 6 days of TM administration. Average AE SD peak serum mirtazapine concentrations after one oral dose of 1.87 mg mirtazapine were 65.1 AE 33.5 ng/mL. Daily 7.5 mg TM administration in healthy cats resulted in a significant increase in appetite in comparison to placebo with serum concentration within the same range of single oral 1.87 mg mirtazapine administration. Evidence suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) are helpful for post-operative pain control in animals. The anti-inflammatory properties of NSAIDs involve an inhibition of cyclooxygenase (COX) isoforms including COX-1 and COX-2. Nontheless, the efficacy of non-selective COX inhibitor (tolfenamic acid) and selective COX-2 inhibitor (robenacoxib) for post-operative pain control in cats has not been compared. The purpose of a present study was to study the postoperative analgesic effects of tolfenamic acid and robenacoxib in cats undergoing ovariohysterectomy.