Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_226
Snippet: Twenty-eight healthy euthyroid dogs were administered levothyroxine (mean dose 0.024 mg/kg every 24 hours) for either 8 weeks (Group 1) or 16 weeks (Group 2). The dose of levothyroxine was adjusted weekly until a target total thyroxine (T 4 ) serum concentration of 40-70 nmol/L was obtained 4-6 hours post pill. Serum concentrations of T 4 , free thyroxine (fT 4 ) by equilibrium dialysis, thyrotropin (TSH), and 3,5,3 0 -triiodothyronine (T 3 ) wer.....
Document: Twenty-eight healthy euthyroid dogs were administered levothyroxine (mean dose 0.024 mg/kg every 24 hours) for either 8 weeks (Group 1) or 16 weeks (Group 2). The dose of levothyroxine was adjusted weekly until a target total thyroxine (T 4 ) serum concentration of 40-70 nmol/L was obtained 4-6 hours post pill. Serum concentrations of T 4 , free thyroxine (fT 4 ) by equilibrium dialysis, thyrotropin (TSH), and 3,5,3 0 -triiodothyronine (T 3 ) were measured every 4 weeks during supplementation and for 4 months after levothyroxine was discontinued. A mixed model ANOVA followed by Tukey's procedure for multiple comparisons was used to compare thyroid function tests both within and between groups. The level of significance was set at <0.05.
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