Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection

Song, Jae-Hyoung; Shim, Aeri; Kim, Yeon-Jeong; Ahn, Jae-Hee; Kwon, Bo-Eun; Pham, Thuy Trang; Lee, Jongkook; Chang, Sun-Young; Ko, Hyun-Jeong

Human rhinoviruses (HRV) are positive single-stranded RNA viruses belonging to the family Piconaviridae. HRV infection in humans usually causes common cold and mild illnesses, but is sometimes associated with asthma exacerbation and viral upper respiratory tract infection (Bartlett et al., 2008) . HRVs are divided into three distinct species including type A, type B, and type C, with over 100 immunologically noncross reactive HRV serotypes (Park et al., 2012) . Among the HRV serotypes, the majority accounting for 90%, use human intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor and do not bind mouse ICAM-1, whereas the remaining 10% of the minor serotypes including HRV1B use a member of the low-density lipoprotein (LDL-1) receptor family and can bind the mouse counterpart (Bartlett et al., 2008) . Thus, HRV1B is thought to be a suitable model for murine infection.