Selected article for: "arterial blood pressure and blood pressure"
Title: 2015 ACVIM Forum Research Abstract Program
  • Document date: 2015_5_27
    • ID: 3pnuj5ru_137
    Snippet: Persians cats with PKD mutation presented a higher prevalence of myocardial hypertrophy, even before changes in arterial blood pressure and renal function. Hypertrophic cardiomyopathy (HCM) is also a prevalent condition in Persian cat and should be considered in the differential diagnosis. Further studies are necessary to evaluate the causal relationship between PKD and hypertrophy or the genetic association between PKD and HCM. As a conclusion, .....
    Document: Persians cats with PKD mutation presented a higher prevalence of myocardial hypertrophy, even before changes in arterial blood pressure and renal function. Hypertrophic cardiomyopathy (HCM) is also a prevalent condition in Persian cat and should be considered in the differential diagnosis. Further studies are necessary to evaluate the causal relationship between PKD and hypertrophy or the genetic association between PKD and HCM. As a conclusion, it is necessary the cardiovascular evaluation of PKD positive cats (as some may have cardiovascular abnormalities); and it is important to include the PDK (even in early stages) as a differential diagnosis of HCM in Persians cats. ASSESSMENT OF THE EFFECTS OF CARVEDILOL, CYCLOSPORIN-A AND SILDENAFIL CITRATE ON DOXORUBICIN-INDUCED CARDIOMYOPA-THY IN AN EXPERIMENTAL MODEL WITH RABBITS. Fernando A Rosa 1 , Felipe K Adams 1 , Murillo D Kirnew 1 , Fabio N Gava 2 , Aparecido A Camacho 1 . 1 São Paulo State University, Jaboticabal, São Paulo, Brazil, 2 Unicastelo University, Descalvado, São Paulo, Brazil Doxorubicin is one of the most effective chemotherapeutic agents currently available. However, its use has been limited by its cardiotoxic effect, especially when used for a long time, leading to iatrogenic cardiomyopathy related to the cumulative dose administered. Because of the refractoriness of its cardiotoxic effects, the prevention plays a singular role. With this purpose, carvedilol, cyclosporin A and sildenafil citrate were tested to assess its cardioprotective action in an experimental model of doxorubicin-induced cardiomyopathy with rabbits.

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