Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_225
Snippet: Results: All phase I dosing cohorts were well tolerated and the DOX (30 mg/m2 q3wk)/CTX (15 mg/m 2 /d) combination was deemed safe. The subsequent 16 randomized dogs tolerated the combination without significant toxicity. No significant difference was observed in relative and absolute Treg numbers between dogs receiving DOX vs dogs receiving DOX/CTX. However, DOX alone and in combination with CTX resulted in significant decreases in absolute lymp.....
Document: Results: All phase I dosing cohorts were well tolerated and the DOX (30 mg/m2 q3wk)/CTX (15 mg/m 2 /d) combination was deemed safe. The subsequent 16 randomized dogs tolerated the combination without significant toxicity. No significant difference was observed in relative and absolute Treg numbers between dogs receiving DOX vs dogs receiving DOX/CTX. However, DOX alone and in combination with CTX resulted in significant decreases in absolute lymphocyte counts (p=0.0007) and a trend towards decreasing absolute Treg numbers.
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