Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_226
Snippet: Conclusion: Metronomic CTX at published dosages can be safely given concurrent with MTD-DOX in tumor-bearing dogs. It is likely that any difference in Treg numbers resulting from the addition of metronomic CTX to MTD-DOX chemotherapy is not observable due to lymphocyte depletion caused by DOX alone in this small cohort. ( Background: Transitional cell carcinoma (TCC) is the most commonly diagnosed tumor of the canine urinary system. Overall survi.....
Document: Conclusion: Metronomic CTX at published dosages can be safely given concurrent with MTD-DOX in tumor-bearing dogs. It is likely that any difference in Treg numbers resulting from the addition of metronomic CTX to MTD-DOX chemotherapy is not observable due to lymphocyte depletion caused by DOX alone in this small cohort. ( Background: Transitional cell carcinoma (TCC) is the most commonly diagnosed tumor of the canine urinary system. Overall survival with traditional chemotherapy in this disease has not improved for many years, and so additional research into new therapeutic targets is needed. Hedgehog signaling, which regulates normal embryonic development, represents one such target. When activated in adult cells, Hedgehog signaling promotes oncogenesis and has been found to play a central role in human bladder cancer.
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