Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_261
Snippet: Conclusions: Rapamycin administered orally at 0.1 mg/kg achieves measurable blood concentrations. Goals of ongoing studies in tumor-bearing dogs are to determine the optimal dose and frequency to achieve clinically relevant concentrations and to determine toxicity. Introduction: A recent study documented the activity of the antihypertensive medication minoxidil in a murine model of sarcoma. Specifically, minoxidil inhibited in vitro cell migratio.....
Document: Conclusions: Rapamycin administered orally at 0.1 mg/kg achieves measurable blood concentrations. Goals of ongoing studies in tumor-bearing dogs are to determine the optimal dose and frequency to achieve clinically relevant concentrations and to determine toxicity. Introduction: A recent study documented the activity of the antihypertensive medication minoxidil in a murine model of sarcoma. Specifically, minoxidil inhibited in vitro cell migration at 0.5 mM and reduced pulmonary metastasis in mice at 1-3 mg/kg. A proposed MOA involves the down-regulation of the collagenmodifying enzyme PLOD2, which occurred at 0.5 mM minoxidil. The activity of minoxidil and role of PLOD2 as a druggable target in osteosarcoma have yet to be investigated. PK/PD data are needed to clarify the anti-metastatic mechanism of minoxidil.
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