Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_263
Snippet: Results: The IC 50 of minoxidil was~1 mM across all cell lines. PuMA demonstrated metastatic inhibition at minoxidil concentrations ≥1 mM. Plasma minoxidil concentrations achieved after 1-3 mg/kg dosing were in the low micromolar range. PLOD2 was expressed in osteosarcoma in all three species, but only inconsistent PLOD2 knockdown at minoxidil exposures ≥0.5 mM was noted......
Document: Results: The IC 50 of minoxidil was~1 mM across all cell lines. PuMA demonstrated metastatic inhibition at minoxidil concentrations ≥1 mM. Plasma minoxidil concentrations achieved after 1-3 mg/kg dosing were in the low micromolar range. PLOD2 was expressed in osteosarcoma in all three species, but only inconsistent PLOD2 knockdown at minoxidil exposures ≥0.5 mM was noted.
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