Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_295
Snippet: In conclusion, the results of this study show that in addition to fasting blood glucose concentration and glucose tolerance status, diabetic cats in remission have a range of metabolic disturbances compared to control cats, some of which may reflect increased gluconeogenesis. Diabetes mellitus (DM) is a common endocrine disorder in cats. Most cats have a form of DM equivalent to type-2 diabetes (T2D) in humans. One new therapeutic strategy for T2.....
Document: In conclusion, the results of this study show that in addition to fasting blood glucose concentration and glucose tolerance status, diabetic cats in remission have a range of metabolic disturbances compared to control cats, some of which may reflect increased gluconeogenesis. Diabetes mellitus (DM) is a common endocrine disorder in cats. Most cats have a form of DM equivalent to type-2 diabetes (T2D) in humans. One new therapeutic strategy for T2D in humans involves use of synthetic incretin hormones, including Exenatide, a GLP-1 hormone agonist. These can be used alone or as an adjunct treatment with insulin to improve overall glycemic control and promote weight loss. Use of Exenatide has recently been shown to be safe and effective at lowering blood sugar concentrations and promoting weight loss in healthy cats. Given the significant benefits seen in people with T2D, and the similar nature of the disease in cats, a clinical trial to assess Exenatide in diabetic cats was warranted.
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