2016 ACVIM Forum Research Abstract Program

Methods: Dogs with cytologically or histologically diagnosed tumors of any histology (excluding mast cell tumors) and any stage were allowed. A standard, open-label, phase I, 3 + 3 dosecohort escalation design was employed. The toceranib dose remained constant at 2.75 mg/kg administered orally every other day. Doxorubicin was initiated at 20 mg/m2 administered IV every 21 days for four doses. The doxorubicin dose was escalated by 5 mg/m2 each cohort until MTD or 30 mg/m2 was reached. DLT was defined as any grade 3 adverse event with the exception of hematopoietic AEs for which a grade 4 AE was considered dose limiting. Any grade AE that was refractory to supportive care or persisted beyond seven days was also considered dose-limiting.