2015 ACVIM Forum Research Abstract Program

.5 ng/mL and dialysis free thyroxine < 0.82 ng/dL). Fasting triglyceride and cholesterol measurements during hospitalization identified the presence of HYPERTRI (triglycerides > 150 mg/dL) and HYPERCHOL (cholesterol > 300 mg/dL). Twenty-one (42%) dogs in group 1 had HYPERTRI, 18 (36%) had HYPERCHOL, 11 (22%) had adrenomegaly, nine (18%) were diagnosed with DM, five (10%) were diagnosed with HAC, two (4%) were diagnosed with HYPOT. In group 2, 12 (29.26%) dogs had HYPERCHOL, five (12.19%) had HYPERTRI, two (4.87%) had adrenomegaly, two (4.87%) were diagnosed with HAC, two (4.87%) were diagnosed with HYPOT, one (2.43%) was diagnosed with DM. DM, adrenomegaly and HYPERTRI showed significant association (p ≤ 0.05) with pancreatitis. The inclusion of the variable DM in the logistic regression model showed no significance, mainly due to colinearity with the variable HYPERTRI. Dogs with HYPER-TRI and adrenomegaly had increased odds ratio (OR=5.3 and 7.2 respectively; 95% confidence intervals) for pancreatitis. Results in this study suggested that HYPERTRI and possibility of HAC (represented by adrenomegaly) are associated with pancreatitis in dogs. An association has been suggested between developing acute pancreatitis (AP) and concurrent endocrinopathies including diabetes mellitus (DM), hyperadrenocorticism (HAC) and hypothyroidism, although no conclusive data are available to confirm it. Moreover, there has been much debate whether hormone imbalances can directly affect the development of AP and/or whether hyperlipidemia induced by endocrinopathies might play a role. The objectives of the present study were to examine the prevalence of AP in dogs with endocrinopathies and to examine the association between those endocrinopathies and hyperlipidemia in dogs with AP. Medical records of 104 dogs newly-diagnosed with AP from 2012 to 2014 were examined for the presence or absence of HAC, DM, and hypothyroidism. Two age-and breedmatched randomized controls for each AP dog were examined for the same endocrinopathies. A matched case-control analysis was performed, and the association between hyperlipidemia and endocrinopathies in the AP group was subsequently evaluated using binary logistic regression analysis.