2015 ACVIM Forum Research Abstract Program

Plasma amlodipine concentration was determined for 97 cats with adequate SBP control (A: 57 cats; B: 40 cats). SBP at the hypertensive visit differed significantly between groups (A: 185.9 AE 14.6 mmHg; B: 208.5 AE 24.4 mmHg, P < 0.001), but comparable post-treatment SBP was achieved (A: 142.4 AE 12.1 mmHg; B: 144.3 AE 10.3 mmHg, n.s.). Plasma amlodipine concentration was twice as high in cats on 1.25 mg compared to those receiving 0.625 mg (70.5 [48.9, 98 .7] ng/mL vs. 33.3 [25.5, 54.9] ng/mL), as was the dose in mg/kg that the cats were receiving (A: 0.17 AE 0.04 mg/kg; B: 0.33 AE 0.09 mg/kg). Dose in mg/kg, plasma amlodipine concentration, and potassium were associated with the absolute change in SBP in the univariable analysis (P < 0.1). The plasma amlodipine concentration and the dose in mg/kg remained positively and significantly associated with decrease in SBP in the multivariable model (P < 0.05).