2015 ACVIM Forum Research Abstract Program

TVA morphology was variable. Alterations of these structures might influence phenotypic heterogeneity of feline cardiomyopathy and merits further study. The urine aldosterone to creatinine ratio (UAldo:C), using a 'spot' sample has been correlated to the 24-hour urine aldosterone excretion in the dog. Evaluation of the UAldo:C can be used to assess the status of a patient's renin-angiotensin-aldosterone system (RAAS). Aldosterone, a major effector molecule of RAAS, has been associated with perpetuation and progression of heart failure. Monitoring of the UAldo:C may help guide pharmacotherapy and determine which patient's may benefit from mineralocorticoid receptor blockade. The UAldo:C in 34 normal, 1-6 year old dogs in the authors' laboratory is 0.40 AE 0.21 lg/g. Only one dog had a UAldo:C greater than 1.0.