2016 ACVIM Forum Research Abstract Program

Dogs receiving polytherapy had a significant increase in becoming agitated when their owner or others show affection for another person during preictal (P = 0.005), postictal (P = 0.001) and interictal (P r = 0.0083) period and when their owner or others show affection for another dog or animal during preictal (P = 0.0068), postictal (P = 0.0068) and interictal (P = 0.02) period when compared to dogs on monotherapy. The finding of behavioral changes present throughout different seizure phases in this study raises further questions about how epilepsy affects canine patient's quality of life. Background: Canine osteosarcoma (OS) is an aggressive sarcoma characterized by pathologic skeletal resorption and pulmonary metastases. A limited number of negative prognostic factors, including bone alkaline phosphatase, have been identified in dogs diagnosed with OS; however, the biologic underpinnings for such observations have not been thoroughly investigated. Endothelin-1 mediated signaling is active during bone repair, and is responsible for osteoblast migration, proliferation, and bone alkaline phosphatase expression.