Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_156
Snippet: Conclusions and clinical importance: Canine OS cells express endothelin-1 and functional endothelin A receptors; with the potential for an autocrine or paracrine pro-tumorigenic signaling loop. Elevations of bone alkaline phosphatase are associated with osteoblastic OS lesions, and might be an epiphenomenon of active endothelin-1 signaling or excessive osteoproduction within the localized bone microenvironment. Introduction: Combination chemother.....
Document: Conclusions and clinical importance: Canine OS cells express endothelin-1 and functional endothelin A receptors; with the potential for an autocrine or paracrine pro-tumorigenic signaling loop. Elevations of bone alkaline phosphatase are associated with osteoblastic OS lesions, and might be an epiphenomenon of active endothelin-1 signaling or excessive osteoproduction within the localized bone microenvironment. Introduction: Combination chemotherapy holds the promise of improved outcome in canine malignancy, but care must be taken to avoid overlapping toxicity.
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