2015 ACVIM Forum Research Abstract Program

The myelosuppression in these cases was consistent with trichothecene intoxication, which is poorly documented both in horses and from a forage source. The clinical course of these cases suggests that spontaneous recovery is possible following severe myelosuppresion due to tricothecene intoxication in horses. Placentitis is an important cause of pregnancy loss and neonatal death in mares. Fetal hypoxia and placental abnormality can be associated with hyperlactatemia in foals; however, data on field cases is scant. The objective of this study was to measure lactate in plasma of foals born from mares suffering with placentitis and from mares carrying and delivering normal pregnancies. A total of 58 Thoroughbred newborn foals were included in this study. Immediately after placental passage, fragments of chorioallantois and amnion were collected and preserved in formalin for histopathologic evaluation. Immediately post-delivery and by 24 hour of birth, each foal underwent clinical examination and blood sampling Plasma lactate was determined by spectrophotometry using a commercial colorimetric kit. Based on placental histopathology and clinical evaluation foals were allocated into four groups as follows: group I (healthy control n = 22) no placental lesions and apparently health foals, group II (placentitis and apparently healthy n = 12), group III (placentitis and abnormal upon clinical examination); and group IV (immature foals and placenta with histopathological lesions compatible with placentiti n = 10). Normality of the data was assessed by Shapiro-Wilk test. Oneway ANOVA was used to evaluate the lactate concentrations in different groups Significance was set at P < 0.05. Concentrations of lactate were significantly increased in groups III and IV at 24 hours after birth; however, foals in groups I and II concentrations presented a reduction in lactate from birth to 24 hours post-delivery. Our findings demonstrate that lactate can be used to identify sick foals which screen apparently normal foals born from mares with placentitis. It is important to emphasize that groups I and II presented lactate concentrations within normal ranges, demonstrating full capacity of neonatal adaptation of group II, despite placental pathology. Borrelia burgdorferi causes Lyme disease via Ixodes scapularis and pacificus tick vectors. A safe and effective vaccine is essential in the prevention of equine Lyme borreliosis. A USDA canine approved outer surface protein A (OspA) vaccine may be promising in this regard and has been used by many equine practitioners. The purpose of this study was to identify the humoral immunogenicity of this vaccine in horsess Forty-three healthy horses were identified for this study. These horses were selected for their improbable contact with Borrelia burgdorferi due to their life long desert habitat. Serological testing for OspA+C+F was completed prior to vaccination. Group-TD (20 horses, mixed breed, five females, 15 geldings) was administered 1 mL (1/2 mL/site) vaccine transdermally over the pectoral region. Group-SQ (20 horses, mixed breed, four females and 16 geldings) were administered 2 mL at the right cervical region. Group-C (3 horses, mixed breed 2 females and 1 gelding) were untreated. Vaccine was administered on day 0 and 21, and 225. Antibodies to OspA + C + F were quantified on day À45, 22, 42, 93, 179, 244, 313, 361 using diagnostic laboratory multiplex assay. At day 41 all horses responded. Median Fluorescent Int