2015 ACVIM Forum Research Abstract Program

Frontal sinusitis should be considered as a differential diagnosis in beef cattle presenting with non-localizing clinical signs. Ancillary diagnostic findings may also be nonspecific. Bucking bulls performing in rodeos are required to have the tips of their horns blunted to a diameter of 3.8 cm (1.5 inches). This procedure may result in opening of or bacterial translocation into the frontal sinus contributing to the development of frontal sinusitis in these animals, particularly in young adults. With appropriate treatment, prognosis for long-term survival is good even in chronic cases. The objective of this study was to compare the plasma pharmacokinetic profile of ceftiofur crystalline free acid (CCFA) and ceftiofur sodium in neonatal calves. In one group, a single dose of CCFA was administered subcutaneously (SQ) at the base of the ear at a dose of 6.6 mg/kg of body weight. In a second group, a single dose of ceftiofur sodium was administered SQ in the neck at a dose of 2.2 mg/kg of body weight. Concentrations of desfuroylceftiofur acetamide were determined in the plasma of all animals.