Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_173
Snippet: One hundred and twenty six dogs were included. All received ONCEPT TM . Sixty had adequate local control (ALC; complete excision or irradiation of microscopic disease). Fifteen were treated in the microscopic setting. Fifty-one were treated in the gross disease setting, of which 39 underwent RT. Median time to progression, median progression-free survival and median overall survival were 304, 244 and 617 days, respectively. Dogs with ALC had impr.....
Document: One hundred and twenty six dogs were included. All received ONCEPT TM . Sixty had adequate local control (ALC; complete excision or irradiation of microscopic disease). Fifteen were treated in the microscopic setting. Fifty-one were treated in the gross disease setting, of which 39 underwent RT. Median time to progression, median progression-free survival and median overall survival were 304, 244 and 617 days, respectively. Dogs with ALC had improved clinical outcomes. The following also correlated with favorable clinical outcomes: rostral location, stage 1, absence of LN metastasis, low mitotic index, absence of bony lysis, absence of gross disease. This is the largest reported series of dogs with OM treated with ONCEPT TM . Clinical outcomes are similar to those reported recently for dogs treated with surgery and/or RT alone. Several prognostic indicators were confirmed. A prospective, randomized, controlled study is needed to determine the clinical benefit of ONCEPT TM .
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