2016 ACVIM Forum Research Abstract Program

Aspart is rapidly absorbed following SC and IM injection in healthy cats. The effective and predictable glucose lowering effect of insulin aspart may be advantageous in the treatment of DKA in cats. Obesity is a major risk factor for the development of diabetes in cats. Recently, retinoid-related orphan receptor gamma (RORc) has been identified as an important transcription factor in the development of large insulin-resistant adipocytes. RORc can be inhibited by its ligand tetra-hydroxylated bile acid (THBA). Oral supplementation of THBA reduces adipocyte size, improves insulin sensitivity and prevents hyperglycemia in obese mice. The purposes of this study were to investigate palatability and possible side effects of THBA, and the effects of THBA supplementation on adipocyte size and insulin sensitivity in healthy cats.