2016 ACVIM Forum Research Abstract Program

These results suggested that mosapride enhances postprandial gallbladder motility. Although the mechanisms of this effect are still to be clarified, our results suggested that mosapride enhances gallbladder motility possibly via gallbladder 5-HT 4 receptor and motilin does not play a role in this effect. Further studies are needed to support our results. Tritrichomonas foetus (Tf) is a flagellated protozoan parasite that is recognized as a significant cause of diarrhea in domestic cats with a prevalence rate as high as 30%. No drugs have been shown to consistently eliminate Tf infection in all cats. Cysteine proteases (CPs) have been identified as mediators of Tf-induced adhesion-dependent cytotoxicity to the intestinal epithelium. Thus, CPs represent novel targets for the treatment of feline trichomonosis. However, cats also produce CPs that are part of life-critical systems. Thus, parasitic CPs need to be selectively targeted to reduce the potential for host toxicity. Previous studies have demonstrated the importance of a specific CP, CP30, in mediating bovine and human trichomonad cytopathogenicity. Thus, the aims of this study were to characterize the presence of CP30 in feline Tf isolates and to evaluate the effect of targeted inhibition of CP30 on feline Tf-induced adhesion dependent cytotoxicity.