Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_425
Snippet: Paraffin-embedded liver specimens from 50 dogs were selected from the tissue archives at Texas A&M University and North Carolina State University. Two contiguous sections were cut from each specimen, one was stained with hematoxylin and eosin (H&E) and one with picrosirius red (PR). Six board-certified veterinary pathologists assigned a fibrosis score (0: absent, 1: mild, 2: moderate, 3: marked, or 4: very marked) to each section using a scoring .....
Document: Paraffin-embedded liver specimens from 50 dogs were selected from the tissue archives at Texas A&M University and North Carolina State University. Two contiguous sections were cut from each specimen, one was stained with hematoxylin and eosin (H&E) and one with picrosirius red (PR). Six board-certified veterinary pathologists assigned a fibrosis score (0: absent, 1: mild, 2: moderate, 3: marked, or 4: very marked) to each section using a scoring system adapted from the Ishak scoring system that is used in humans. Interobserver agreement for the H&E and PR stained sections was evaluated using the kappa and weighted-kappa statistics. The median fibrosis score assigned to H&E and PR stained sections from each dog were compared using the Wilcoxon signedrank test.
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