Selected article for: "branch site and mammalian lineage"
Author: Joana Damas; Graham M. Hughes; Kathleen C. Keough; Corrie A. Painter; Nicole S. Persky; Marco Corbo; Michael Hiller; Klaus-Peter Koepfli; Andreas R. Pfenning; Huabin Zhao; Diane P. Genereux; Ross Swofford; Katherine S. Pollard; Oliver A. Ryder; Martin T. Nweeia; Kerstin Lindblad-Toh; Emma C. Teeling; Elinor K. Karlsson; Harris A. Lewin
Title: Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates
  • Document date: 2020_4_18
    • ID: 6ne76rh1_54
    Snippet: In addition to site-models, branch-site model A1 (null model) and model A (alternative model) were also implemented targeting various mammalian orders, specifically Chiroptera, Cetartiodactyla, Rodentia and Primates, to identify lineage-specific positive selection in the ACE2 receptor sequence. Branch-site Model A1 constrains both the target foreground branch (Carnivora, Chiroptera, Cetartiodactyla, Rodentia and Primates) and background branches .....
    Document: In addition to site-models, branch-site model A1 (null model) and model A (alternative model) were also implemented targeting various mammalian orders, specifically Chiroptera, Cetartiodactyla, Rodentia and Primates, to identify lineage-specific positive selection in the ACE2 receptor sequence. Branch-site Model A1 constrains both the target foreground branch (Carnivora, Chiroptera, Cetartiodactyla, Rodentia and Primates) and background branches to ⍵<=1, while the alternative Model A allows positive selection to occur in the foreground branch. Null and alternative models were compared using LRTs as above, with significant BEB sites identified.

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