2016 ACVIM Forum Research Abstract Program

Six healthy purpose-bred cats were fed 5 mg/kg/day of THBA for 8 weeks. THBA was given in a small amount of food to each cat individually before the daily ration was offered. Complete blood count, biochemical profile and insulin tolerance test (ITT; 0.1 IU/kg insulin aspart IV) were performed at weeks 0 and 8. After 12-18 hours of fasting blood glucose concentration was recorded and the rate constant for the disappearance of glucose (K ITT ) was calculated. Subcutaneous fat tissue samples were taken in the umbilical area by a 4 mm biopsy punch, and adipocyte size was determined by histological and image based analysis of at least 10 sections per animal. Data were analyzed by parametric tests (P < 0.05).