Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_271
Snippet: The intestinal microbiota has been recently linked to the development of human metabolic diseases including diabetes mellitus (DM), due to its role in energy balance, gut permeability, and host inflammatory state. Microbial imbalances may also affect bile acid (BA) metabolism through altered profiles of primary and secondary BA, which modulate signaling pathways involved in insulin resistance via GLP-1 induction. Characterization of the intestina.....
Document: The intestinal microbiota has been recently linked to the development of human metabolic diseases including diabetes mellitus (DM), due to its role in energy balance, gut permeability, and host inflammatory state. Microbial imbalances may also affect bile acid (BA) metabolism through altered profiles of primary and secondary BA, which modulate signaling pathways involved in insulin resistance via GLP-1 induction. Characterization of the intestinal microbiota and BA in dogs with DM has not been systematically evaluated. Therefore, the aim of this study was to investigate the fecal microbiota and BA composition of healthy dogs and dogs with DM.
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