2016 ACVIM Forum Research Abstract Program

Data were first assessed as independent events by analyzing only the results of the first serum biochemistry profile obtained for each cat (n = 1314). The median lipase value in the group of cats with creatinine values above reference interval (>190 µmol/L, n = 162) was 18.5 U/L (range 7-594 U/L), which was higher (P < 0.001) than the median lipase value of 14 U/L (range 5-747 U/L) in the group of cats with creatinine values ≤190 (n = 1152), although ranges overlapped substantially. The same trend (P = 0.06) was observed for PLI in these respective groups: median was 16.6 µg/L (range 1.5-50 µg/L) for cats with creatinine >190 µmol/L (n = 9); median was 3.85 µg/L (range 0.5-50 µg/L) for cats with creatinine ≤190 µm/L (n = 55). There was a significant, but weak, correlation between creatinine and lipase values across all cats (rho=0.2, P < 0.001, n = 1314), but no correlation was present for the group of cats with creatinine values >190 µmol/L (n = 162). There was no correlation between creatinine and PLI. Multivariate linear regression was used to assess the influence of creatinine, hydration, and body condition on lipase over all cats for which this information was available (n = 313); none of these variables demonstrated a significant effect (P = 0.09, 0.22, and 0.97, for creatinine, hydration, and body condition, respectively). The data were next assessed by MANOVA for variation over time within individual cats for which repeat serum biochemistries and medical record data were available (n = 279). Hydration demonstrated a significant effect on creatinine (P < 0.001), and a trend towards effect on lipase (P = 0.07). Creatinine did not demonstrate any further relationship with lipase (P = 0.39). PLI was repeated in 15 cats; values moved in the same direction as creatinine in only 4 cases.