2016 ACVIM Forum Research Abstract Program

On aggregometry, for Doses A-E, there was a mean decrease in maximum amplitude of 3.8%, 41.3%, 81.3%, 75.9%, and 87.8%, respectively. Compared to Day 0, there was a significant decrease on Day 7 for Doses B-E. The maximum amplitude was decreased >25% (indicating aspirin responsiveness) in all dogs receiving Dose C or greater. Similar to aggregometry, when the PFA-100 Ã’ closure times on Day 0 were compared to Day 7, there was a significant increase for Doses B-E. On Day 7, for Doses A-E, mean PFA-100 Ã’ closure time was >300 seconds (indicating aspirin responsiveness) in 0%, 25%, 62.5%, 87.5%, and 87.5%, respectively. Compared to Day 0, there was a significant decrease on Day 7 for the concentrations of 11-dTXB 2 (P = 0.0003) and 6-keto-PGF1 a (P = 0.0075). However, the changes in 11-dTXB 2 and 6-keto-PGF1 a were not dependent on aspirin dose.