2016 ACVIM Forum Research Abstract Program

Prevalence of anemia was significantly higher in dogs with lymphoma than dogs with IBD (P = 0.02) and healthy dogs (P = 0.0001), and significantly higher in stages 4 and 5 lymphoma as compared to stage 1, 2 or 3 (P = 0.045). There was a significantly higher total number of RBC morphological anomalies in the peripheral blood of dogs with lymphoma as compared to dogs with IBD (P = 0.02) and healthy dogs (P < 0.0001). Dogs with sub-stage b lymphoma also had a higher prevalence of total RBC morphologic anomalies as compared to sub-stage a (P = 0.04). When categorized by pathologic etiology, dogs with lymphoma had a significantly higher number of RBC anomalies associated with regenerative anemia (P < 0.0001), oxidative stress (P = 0.002), and other RBC anomalies (P < 0.0001) when compared to healthy dogs, but no significant difference when compared to dogs with IBD. The prevalence of eccentrocytes was significantly higher in dogs with lymphoma compared to IBD (P = 0.03), as well as healthy dogs (P = 0.002). No differences were noted between small, intermediate and large cell lymphoma for all parameters studied.