2016 ACVIM Forum Research Abstract Program

8 dogs with NRIMA referred to Hokkaido university teaching hospital between 2012 and 2015 were included. Inclusion criteria in this research were a minimum 5-day history of anemia, a severe nonregenerative anemia (Hct < 20%) with absolute reticulocyte count < 60 9 10 3 /ll, and absence of any identifiable underlying disease which could induce severe anemia. The following data were collected for each dog: age, breed, sex, results of hematological analyses performed on admission, results of bone marrow examination. First treatment regimen included prednisolone (2 mg/kg/day) and cyclosporine (10 mg/kg/day) for 8 weeks. Good response were defined as an absolute reticulocyte count > 60 9 10 3 /ll or increasing Hct. Dogs that responded within 8 weeks continued to be treated with gradual tapering of dose, and re-evaluated after 6 month. Dogs that did not respond to the first regimen proceeded to second regimen including prednisolone and mycophenolate mofetil (15 mg/kg, twice a day). Similarly, good response for second regimen was determined as explained above and dogs that did not respond to both regimens were defined as poor response.