2016 ACVIM Forum Research Abstract Program

Significantly increased mean concentrations of IL12(p40) (1191 AE 484.9 versus 219.6 AE 393.3 pg/mL; P < 0.0001), SDF1 (2015 AE 1131 versus 528.7 AE 1002 pg/mL; P = 0.002), and IL18 (483.8 AE 468.8 versus 92.03 AE 272.6 pg/mL; P = 0.02) were detected in the serum of cats with IC compared to unaffected cats. Further studies are necessary to evaluate the diagnostic and prognostic utility of serum cytokine biomarkers in cats with IC. The most common radiopaque cystoliths in cats are composed of struvite or calcium oxalate minerals. Struvite cystoliths have been shown to dissolve with dietary management whereas calcium oxalate cystoliths must be removed surgically. The commercially available diet, PurinaÃ’ Pro PlanÃ’ Veterinary Diets UR UrinaryÃ’ St/OxÃ’, has been formulated for the dissolution of struvite cystoliths and to lessen the recurrence of both struvite and oxalate cystoliths. The purpose of this study was to describe the clinical and laboratory findings in cats with radiopaque cystoliths fed this commercially available diet.