2016 ACVIM Forum Research Abstract Program

This study is the first step towards improving treatment of various autoimmune diseases in cats. The results of this study suggest that the infusion of MMF once at 20 mg/kg 12 hs apart, provides a safe and rapid immunosuppressive effect in cats. Future studies will evaluate the pharmacokinetics and the effect of MPA on target lymphocyte subpopulations (CD25 + CD8 + and CD25 + CD4 + T cells) following multi-day intravenous and oral dosing of MMF. Preparation choice reflected current prescribing practices and routinely utilized concentration. Samples were acquired by prescription from two national veterinary compounding pharmacies at three time points spanning a 30-day period. Two different storage conditions were evaluated and sampled at four time points from the order date (Day 7, 14, 21, and 28) . MO recovery was performed by solid-phase extraction and concentration strength measured via high-performance liquid chromatography.