Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_674
Snippet: These data demonstrate that, under these conditions, levamisole downregulates conA stimulated PBMC proliferation. Based on these in vitro results, further studies to determine the effectiveness of levamisole on modulating the equine immune system in vivo are warranted. Atrial fibrillation (AF) is the most common pathological arrhythmia diagnosed in horses. Due to the adverse effects encountered when treating with quinidine sulphate we wanted to i.....
Document: These data demonstrate that, under these conditions, levamisole downregulates conA stimulated PBMC proliferation. Based on these in vitro results, further studies to determine the effectiveness of levamisole on modulating the equine immune system in vivo are warranted. Atrial fibrillation (AF) is the most common pathological arrhythmia diagnosed in horses. Due to the adverse effects encountered when treating with quinidine sulphate we wanted to improve the medical treatment of AF. In this study we aimed to evaluate the effects of the antiarrhythmic compounds dofetilide and ranolazine in the equine heart. Furthermore, we hypothesized that the use of a combination of two antiarrhythmic compounds with distinct mechanisms would allow us to use lower doses of each compound and thereby minimize the risk of adverse effects.
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