2016 ACVIM Forum Research Abstract Program

The objective of this study was to determine the short-term and long-term prognosis in recumbent adult dairy cows who underwent C0-Initial plasma concentration; AUC-Area under the curve; T1/2 α and β-Distribution and elimination half-life; Vss-Volume of distribution at steady state; Cl-Clearance CSF analysis. The previously mentioned threshold values for TNCC and protein concentration were used. We hypothesized that recumbent cows with CSF values higher than the pre-determined threshold values would have a less favorable short-term and longterm prognosis. All dairy cattle, of 2 years or more of age, that were recumbent and who have had a CSF analysis were included in the study (n = 214 cases). CSF analysis was performed by board certified pathologists, and only CSF analysis which contained both the TNCC and protein concentration were included in the study. A successful short-term prognosis was based on the return to the farm. A successful long-term prognosis was based on the completion of at least one lactation using the Canadian Dairy Network database. Statistical analysis was performed using the Chi-squared test to compare numbers of cows in each group. Age of patients ranged from 2.0 to 14.5 years (median 5.6 years). Two hundred and eight cows were Holstein, 4 were Ayrshire and 2 were Jersey. The duration of hospitalization ranged from 1 to 48 days (median 7 days). In cows for which the information was available, days in milk ranged from 1 to 516 days (median 25 days) and 18% of the cows (23/130) were dried. Of the 214 cases studied, 167 cows had CSF values for TNCC and protein concentration below the threshold values, and 47 cows had CSF values above the pre-determined threshold values.