Title: 2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018 Document date: 2018_10_25
ID: 60ceejq1_12
Snippet: The results of this study suggest that sotalol has negative inotropic and chronotropic effects in healthy dogs. Standard echocardiographic measurements of systolic function showed a small but statistically significant decrease after sotalol treatment, with a mean reduction in EF (SMOD) of 5.8%. The lack of significance for 3D imaging may reflect the variability in 3D measurements and the small sample size. The effects of sotalol in dogs with stru.....
Document: The results of this study suggest that sotalol has negative inotropic and chronotropic effects in healthy dogs. Standard echocardiographic measurements of systolic function showed a small but statistically significant decrease after sotalol treatment, with a mean reduction in EF (SMOD) of 5.8%. The lack of significance for 3D imaging may reflect the variability in 3D measurements and the small sample size. The effects of sotalol in dogs with structural heart disease should be prospectively assessed to further elucidate the clinical significance of decreased systolic function, and the implications of this reduction in patients at risk for heart failure.
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