2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Our findings indicate that a sizeable portion of CSM-affected dogs suffer from combined compressions. It is important to routinely and carefully evaluate all cervical levels to make sure these are not overlooked, as the high proportion of spinal cord hyperintensity may suggest they represent a more severe form of the disease. Formalin-fixed, paraffin-embedded sections from 5 GME and 3 NME (total 8 dogs) samples were used in this study. Staining for PDGFR-α, PDGFR-ß, VEGFR-2, c-Abl, and c-Kit was carried out using standard immunohistochemical procedures developed for use in formalin fixed tissues. Immunohistochemical evaluation assessed staining positivity of each TKs and staining intensity and distribution of TK positive cells.