2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Faecal consistency was described as abnormal in 80% of dogs in the probiotic group and 83% in the placebo group. Faecal frequency was increased in 51% of dogs in the probiotic group and 44% in the placebo group. There was no difference in the diarrhoea event scores whilst the dogs took either trial product (p > 0.05). In addition, there was no difference in QoL score between each trial period, but there was a significant correlation between QoL and diarrhoea score; QoL was considered to be worse when the diarrhoea was more severe (p < 0.0001). Also, there was a significant correlation between QoL and tumour type; dogs with lymphoma were described as having a significantly worse QoL compared to dogs with sarcomas or carcinomas to the unique nature of the nanoparticle design they vibrate when exposed to the appropriate wavelength of light generating controlled and targeted heat. Our hypothesis is that heat generated with laser light induced nanoparticle vibration will cause cancer cell death, thereby provide definitive therapy in low grade mast cell tumors.